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Synthetic Lethality BioDiscovery Portal


*** Latest News: Phase II of SL-BioDP released: three new drug related analyses are added ( For more information, please read  Gene drug sensitivity; Gene drug correlation; Drug Induced Perturbation)


The Synthetic Lethality BioDiscovery portal (SL-BioDP) is a comprehensive web tool for systematic exploration and functional analysis of cancer-specific synthetic lethal (SL) interactions of known cancer susceptibility genes. It hosts SL interactions predicted using DiscoverSL: a machine-learning algorithm for multi-omic TCGA cancer data-driven synthetic lethal interactions. It provides extensive cross-references and user friendly querying interfaces to support SL-related research. This web portal currently hosts SL interactions for 18 cancer types (Portal Data Summary).


*** We recommand using Chrome and Firefox. Some functionalities may not be well supported On Internet Explorer (IE).


  • Search by one or more HUGO gene symbols or Entrez ID

    • For prediction of SL interactions, search is limited to the cancer survival SL Primary Gene list Please wait ...
    • Results of SL predictions and drug interactions are presented by sequential selection of provided options by the user
    • Results are summarized into 3 main pages initiated by gene search:
      1. Selection of Cancer types
      2. Selection of SL pairs
      3. Drug interaction
      •
Gene Search

Gene Symbol
Entrez Gene ID

Enter gene list:

OR Upload gene list from file:



  • Search by cancer type to view the mutation status in the cancers for the selected genes

    • Results of SL predictions and drug interactions are presented by sequential selection of provided options by the user
    • Results are summarized into 3 main pages initiated by cancer type search:
      1. Selection of Genes
      2. Selection of SL pairs
      3. Drug interaction
Please select cancer type



Please wait ...

Yes No Please wait ...



  • Search by drug name or Pubchem chemical index (CID) number to show genes reported to interact with the selected drug

    • Results of SL predictions and drug interactions are presented by sequential selection of provided options by the user
    • Results are summarized into 4 main pages initiated by drug search:
      1. Gene drug interactions (sourced from DGIdb or Drug bank); The presented drug target(s) will query against the SL interatction database as SL interactor gene;
      2. Selection of Cancer types
      3. Selection of SL pairs
      4. Drug interaction

Drug Search

Drug Name
CID

Enter drug list:
OR Upload drug list from file:


Select Drug Target Database (DrugBank and DGIdb) :

Select Parameters:

Yes No Please wait ...


User Manual

If you use SL-BioDP in any published work, please cite both the software (as an electronic resource/URL) and the paper listed below

  • Contact US

    • Bioinformatics core facility
    • Radiation Oncology Branch
    • National Cancer Institute
    • National Institutes of Health, Bethesda, MD 20892
    • For any suggestions or technical difficulties with this site, please contact us at bioinfo_rob@mail.nih.gov.


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